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Antidepressant medications are indicated to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other necessary benefits. However, studies have shown that a small number of people who administer antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with the attending physician about the risks and benefits of antidepressant medication, even if treatment is not for a mental/mood condition.

Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms being manifested when a new antidepressant is started or when the dose is changed.

Zoloft is used to treat depression, panic attacks, obsessive compulsive disorders, post-traumatic stress disorder, social anxiety disorder (social phobia), and a severe form of premenstrual syndrome (premenstrual dysphoric disorder). This medication may enhance your mood, sleep, appetite, and energy level and may help restore your interest in daily living. It may minimize fear, anxiety, unwanted thoughts, and the number of panic attacks. It may also decrease the urge to perform repeated tasks (compulsions such as hand-washing, counting, and checking) that interfere with daily living. This medication works by helping to restore the equilibrium of certain natural chemicals in the brain.

Read the Medication Guide (US) or Patient Information Leaflet (Canada) available from your pharmacist before you start administering Zoloft and each time you get a refill. If you have any questions, consult your attending healthcare provider.

Take this medication by mouth, usually once daily or as directed by your attending physician. Zoloft may make you sleepy or wakeful. Therefore, it depends on how this medication affects you, your doctor may direct you to take the entire dose once daily either in the morning or evening.

The tablet form of this medication may be taken with or without food. The capsule form is usually taken with food after breakfast or after your evening meal as directed by your doctor.

If you are taking this medication for premenstrual problems, your doctor may direct you to take this drug every day of the month or just for the 2 weeks before your period through the first full day of your period.

The dosage is based on your medical condition and response to therapy. To reduce your risk of side effects, your doctor may start you at a low dose and gradually increase your dose. Usually, the daily dose will not be more than 200 milligrams. Follow your doctor's instructions carefully. Do not take more or less medication or take it more frequently than prescribed. Your condition will not improve any faster and your risk of side effects will increase. Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time each day.

It is important to continue taking this medication as prescribed even if you feel well. Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is abruptly stopped. Your dose may need to be gradually decreased to reduce side effects. Consult your doctor or pharmacist for more details.

It may take up to 4 weeks before the full benefit of this drug takes effect.